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Ketoprofen is a non-steroidal anti-inflammatory drug (NSAID). Oral, rectal, intramuscular, intravenous and topical administration every 6 to 12 hours.
It is excreted in breastmilk in clinically negligibe amounts (Jacqz-Aigrain 2007) and expert authors consider it compatible with breastfeeding (Hale, Davanzo 2014, Jacqz-Aigrain 2007, Janssen 2000, Nice 2000). Its high percentage of protein binding explains the very small transfer to milk observed.
In a French pharmacovigilance study, several possible cases, unconfirmed, were found of the implication of ketoprofen in certain adverse effects in the infant (Soussan 2014). Its pharmacokinetics makes its involvement unlikely.
Most non-steroidal anti-inflammatories may increase jaundice, so it is preferable to avoid them during the neonatal period in mothers of infants with jaundice. (Janssen 2000)
TOPICAL USE: The small dose and the low plasma absorption of most topical dermatological preparations make transfer to breastmilk in significant amounts unlikely. Dermal bioavailability is 5%. (AEMPS 2016)
Ketoprofen is a non-steroidal anti-inflammatory drug (NSAID). Oral, rectal, intramuscular, intravenous and topical administration every 6 to 12 hours.
It is excreted in breastmilk in clinically negligibe amounts (Jacqz-Aigrain 2007) and expert authors consider it compatible with breastfeeding (Hale, Davanzo 2014, Jacqz-Aigrain 2007, Janssen 2000, Nice 2000). Its high percentage of protein binding explains the very small transfer to milk observed.
In a French pharmacovigilance study, several possible cases, unconfirmed, were found of the implication of ketoprofen in certain adverse effects in the infant (Soussan 2014). Its pharmacokinetics makes its involvement unlikely.
Most non-steroidal anti-inflammatories may increase jaundice, so it is preferable to avoid them during the neonatal period in mothers of infants with jaundice. (Janssen 2000)
TOPICAL USE: The small dose and the low plasma absorption of most topical dermatological preparations make transfer to breastmilk in significant amounts unlikely. Dermal bioavailability is 5%. (AEMPS 2016)